PD98059 can adhere to disactivated MEK1 ATP locus to inhibit the effect of Raf, therefore block the phosphysating activation of ERK1/2 by MEK1, PD98059 is an ideal blocking agent for in vitro study on the effect of ERK pathway in cell lines.

• 因此目前有关ERK抑制剂的研究较多,其中PD98059可特异性阻断ERK上游分子MEK对ERK1/2的磷酸化活化,是体外研究ERK通路在细胞中作用的理想阻断剂。