Overexpression or functional abnormality of membrane drug transport proteins of ATP-binding cassette(ABC)family which results in an increased drug efflux,could be one of the main mechanisms.

• 其中,肿瘤细胞膜上ATP结合盒(ABC)转运蛋白的表达或功能异常是肿瘤细胞产生MDR的重要机制之一。