Overexpression of wild-type E6-AP in vivo enhanced the ubiquitination of TH1, whereas a dominant negative E6-AP mutant inhibits its ubiquitination.

• 过表达野生型的E6-AP会增强TH1的泛素化；而过表达泛素连接酶活性缺失E6-AP突变体则会抑制TH1的这种泛素化。