Overexpression of extracellular endosulfatases, enzymes which remove 6-O sulfate groups from heparan sulfate chains, diminishes myeloma tumor growth in vivo.

• 细胞外的内硫酸酯酶，是将6-氧硫酸根基团从肝素硫酸基团链上移除的酶，它可在活体减少骨髓瘤的生长。