Our results provide evidence for a coupled mechanism of 5-meC demethylation, whereby AID deaminates 5-meC, followed by thymine base excision by Mbd4, promoted by Gadd45.

• 如果可以的话，它将能导致新的药物来恢复特定基因活性并抑制肿瘤生长。引人注目的是，这一系统也能帮助基因组免遭突变。