Osteomalacia, osteoporosis and accelerated bone turnover were observed with elevated serum alkaline phosphatase (ALP), osteocalcin (BGP) and parathyroid hormone (PTH) in rats fed on low calcium diet and fluoridized water for 2 months.

• 偏食低钙条件下饮高氟水2个月，引起骨软化和骨质疏松，成骨与破骨活动高度活跃，血清碱性磷酸酶（ALP）、骨钙素、甲状旁腺激素升高。