One Mel resistant subline(L1210/Mel mouse), which is stably 10 fold resistant to Mel, was implanted in the DBA/2 mouse acute lymphocytic leukemia model.

• 建立耐Mel的动物模型L1210 Mel mouse，初步结果表明在体内Mel耐药，将其腹水细胞在体外培养，与敏感株相比，对Mel耐药10倍。