ObjectiveTo transferred the Foxp3 gene into CD25~+CD4~- T lymphocytes and induce it expression, then infuse it to autoimmune disease model to re-establish self-tolerance.

• 这些体内外诱导针对移植器官的免疫耐受的方法原则上能够在自身免疫疾病中重建自身免疫耐受。 目的:通过基因转染技术将Foxp3基因导入CD4~+CD25- T淋巴细胞,使之表达。