Objective:To observe the changes of fentanyl pharmacokinetics in rats during anhepatic phase by treatment of large dose of dexamethasone and to investigate the extrahepatic metabolism of fentanyl.

• 目的:研究大剂量地塞米松处理后大鼠无肝期药代动力学的影响,探讨芬太尼的肝外代谢及地塞米松对其盰外代谢的影响。