Objective:To investigate the role of RhoA-ROCK signal pathway in the reorganization of actin cytoskeleton and the changes of morphology induced by hypoxia in breast cancer cells(MDA-MB-435 cells).

• 目的:探讨缺氧对乳腺癌细胞(MDA-MB-435细胞)肌动蛋白细胞骨架重构和细胞形态改变与RhoA-ROCK信号通路的关系。