Objective:To investigate the molecu larm echan ism of h istone deacetylase inh ib itors(HD Is) in cell cyc le ar-rest and induction of p21WAF1 /C IP1.M ethod s:Hum an cervix carc inom a HeLa cells were used as models.

• 目的:研究组蛋白去乙酰化酶抑制剂(HD Is)诱导肿瘤细胞产生周期阻滞以及诱导p21WAF1/C IP1表达的分子机制。