Objective:To find protective antigen(PA) defective mutants of anthrax toxin with the same function as PA but with low immunogenicity,different domains of PA were mutated.

• 目的:对炭疽毒素保护性抗原(PA)的不同结构域进行了缺失突变,以期找到免疫原性降低而功能变化不大的PA蛋白突变体。