Objective: To evaluate the effects of intraarticular and intraperitoneal injection of melatonin(MLT) on experimental osteoarthritis in rats and to research the OA pathogenesis related to free radical.

• 目的通过观察褪黑激素(M LT)对大鼠膝骨关节炎(OA)软骨的影响,探讨OA的发病机制及M LT不同给药方式对OA的治疗作用。