Objective To reduce extrahepatic side effects of ACV in treatment of chronic hepatitis B , the drug was conjugated with lactosaminated poly L lysine (Lac PLL) which selectively enters hepatocyte by Asialoglycoprotein receptor.

• 目的 减少抗病毒药阿昔洛韦 (Acyclovir ,ACV)在治疗乙型肝炎中的肝外毒副作用 ,获得肝靶向ACV偶联物。