Objective To observe the effects of high glucose on the production of tissue plasminogen activator (t PA) by human glomerular mesangial cells (MC), its binding ability to the cells, and the role of fibronectin (FN) in this event.

• 目的 观察高糖状态下系膜细胞与组织型纤溶酶原激活物 (Tissueplasminogen ,t PA)结合力及系膜细胞产生t PA活性改变与纤维连接蛋白 (Fibronectin ,FN)产生的影响。