Objective To investigate whether aldosterone (Aldo) may be synthesized by glomerular mesangial cells and whether Aldo promotes the synthesis of fibronectin (FN) and type IV collagen in mesangial cells.

• 目的 证明肾脏系膜细胞能够自身合成醛固酮 ,并探讨醛固酮对系膜细胞细胞外基质生成的影响。 方法 用RT PCR法检测大鼠系膜细胞醛固酮合成酶CYP11B2mRNA表达 ,PCR产物存化后直接测序 ;