Objective To investigate the feasibility and effectiveness of low-density lipoprotein (LDL) particles as a carrier of a lipophilic anthracycline drug doxorubicin (ADM) for targeting delivery to leukemic cell.

• 目的 以低密度脂蛋白(low-density lipoprotein,LDL)为阿霉素(adiramycine,ADM)的载体，制备低密度脂蛋白-阿霉素(LDL-ADM)复合物，以游离ADM为对照，体外研究LDL-ADM复合物对白血病细胞株K562、M_2亚型白血病细胞和健康外周血单个核细胞的细胞毒作用。