Objective To investigate the changes of expression of connexin-43(Cx43) and the tight junction of microvessel endothelial cells(EC) to approach the effects in bleomycin(BLM) induced pulmonary fibrosis(PF).

• 目的观察博莱霉素(BLM)造模大鼠肺微血管内皮细胞(EC)紧密连接及Cx43表达的变化特征,探讨其在肺纤维化发生中的作用和意义。