Objective To establish the animal model of EAE (experimental autoimmune encephalomyelitis) to study the inducible suppression of EAE by i.p. administration of soluble MBP (myelin basic protein).

• 目的建立实验性自身免疫性脑脊髓炎(EAE)动物模型,研究腹腔内注射可溶性髓鞘碱性蛋白(MBP)诱导免疫耐受的作用机制。