Objective To detect the alterations of k-ras gene and p15 gene and analyse the genomic instability in the malignant process of 16HBE cells induced by crystalline nickel sulfide(NiS).

• 目的 检测结晶型硫化镍 (NiS)对K -ras基因和P15基因的改变及基因组不稳定性的影响 ,从而进一步探讨镍化合物致癌的分子机制。