Objective To construct a bivalent VP1 gene vaccine against Coxsackie virus B1 and B3 (CVB1 and CVB3) and to test its immunogenicity in mice.

• 目的 构建柯萨奇病毒 (CV)B1/B3型二价VP1基因免疫质粒 ,并探讨其免疫原性。