OBJECTIVES: To improve the effect and safety of high dose methotrexate (HD-MTX) chemotherapy, the metabolic regularity of MTX and its clinical application were discussed.

• 目的：本研究对小儿急性淋巴细胞白血病大剂量甲氨蝶呤化疗时甲氨蝶呤血药浓度的变化规律及其临床应用进行探讨，旨在为提高临床化疗的有效性和安全性。