Nitrovanillic acid was synthesized from vanillic acid, which was obtained by oxidation of vanillin with molten KOH in presence of air, followed by nitration in an overall yield of 82.5%.

• 在空气的存在下；香兰素经熔融氢氧化钾加热氧化制得香兰酸；再经硝化得到5-硝基香兰酸；总收率82.；5%25。本法操作简易；原辅料价廉易得。