Nitrovanillic acid was synthesized from vanillic acid, which was obtained by oxidation of vanillin with molten KOH in presence of air, followed by nitration in an overall yield of 82.

• 在空气的存在下,香兰素经熔融氢氧化钾加热氧化制得香兰酸,再经硝化得到5-硝基香兰酸,总收率82。