Nitric oxide, an intracellular messenger molecule linked to activation of N Methyl D aspartate(NMDA) receptor, plays a role in morphine tolerance and dependence.

• 一氧化氮(NO)是与N甲基D天(门)冬氨酸(NMDA)受体活性相关的一种细胞内信使分子,在吗啡耐受和依赖中起作用。