New screening methods of novel antituberculotic drugs which are effect on the drug resistant and dormant bacillus was reviewed employing both combinational chemistry and functional genomics.

• 为根除结核病,必须开发针对耐药菌和休眠菌的新型抗结核病药物。组合化学和功能基因组学的结合将有助于加快新药开发速度。