NPY can activate the Ca~ 2+ /CaM-dependent calcineurin signaling pathway of cardiomyocytes, and the enhancement of [Ca~ 2+ ] induced by NPY may be the first step in it.

• NPY可活化心肌细胞内Ca2+及CaM-CaN途径。 NPY刺激下产生的细胞内钙增加,可能是其活化CaN途径的始动环节。