N-Cbz-Me-D-Phe were obtained from D-Phe through N-protection with Cbz and N-methylation with NaH/CH3I in an overall yield of 85%.

• 以D-苯丙氨酸为原料,用Cbz保护其氨基后,用NaH/CH3IN-甲基化,得到N-Cbz-Me-D-苯丙氨酸,总收率85%25。 用Cbz保护谷氨酰胺的氨基,在酸性条件下用三苯甲基(Trt)保护谷氨酰胺的侧链酰氨基。