Myocardial apoptosis is an important reason of adriamycin-induced cardiomyopathy. One of the mechanisms might be that ADR can increase Bax protein expression and decrease Bcl-2 protein expression.

• 心肌细胞凋亡是阿霉素心肌病心肌损伤的重要原因，Bax蛋白表达升高，Bd一2蛋白表达降低是其诱发凋亡的机制之一。