Multiplicity analysis showed that individuals with the MTHFR 677TT and 677CT genotypes had a significantly higher risk for developing ESCC (OR=2.36, OR=1.76) and GCA (OR=1.34, OR=1.23) compared to the 677CC genotypes.

• 多因素分析发现；携带677TT基因型和677CT基因型的个体发生食管癌的风险分别是677CC基因型的2.；36倍和1