Much evidence showed that changes in partial oxygen pressure, hormone, cytokine and chemical stimulation could increase ROS, and ROS, acting as signaling molecules, mediates cell functions.

• 许多证据表明，氧分压改变、激素、细胞因子和化学物质等均可引起的ROS增加，作为细胞信号分子，ROS可参与细胞功能的调节。