Modulation of O6-methylguanine-DNA methyltransferase(MGMT) and mismatch repair(MMR) expression in tumors and normal tissue is currently being investigated as a possible strategy ...

• 靶向DNA修复机制增强抗肿瘤化疗药物的疗效、克服肿瘤耐药正成为肿瘤个体化化疗研究的一个重要领域。