Methods:Starting from 5-cyanophthalide, escitalopram oxalate was prepared via several steps including nucleophilic addition, hydrolysis, chemical separation, cyclization and salt formation.

• 方法:以5-氰基苯酞为起始原料,经亲核加成、水解、化学拆分、环化和成盐等反应制得抗抑郁药草酸依地普仑。