Methods:Sixty male SD rats were experienced combination of 5/6 nephrectomy and abdominal cavity injection with midium-dose streptozotocin to establish model rats with DRI.

• 方法:采用5/6肾切除合中等剂量的STZ腹腔注射方法建立糖尿病肾病肾功能不全模型,将造模成功的大鼠50只随机分为5组:模型组(生理盐水2mL/d灌胃);