Methods:Based on Bliss method,the LD_(50) of amoxicillin,metronidazole,colloidal bismuth subcitrate and their combined medication were investigated,respectively,by the mode of po administration to mice.

• 方法:按照Bliss法测定3种药及其相互组合间小鼠灌胃给药的急性毒性(LD50),根据金氏概率相加法分析药物间毒性的交互影响。