Methods: TBA in bile was detected with enzymic method.Bile acid pool size was measured according to the isotope dilution principle.Total fecal bile acid outputs were measured with HPLC.

• 方法：采用第5代循环酶法测定胆汁中胆汁酸，液体闪烁示踪技术测量胆酸池，高效液相色谱测定类便中胆汁酸。