Methods The rat sepsis model was reproduced by cecum ligation and puncture (CLP). One hundred and fortyfour rats were randomly divided into normal control group, sham operation group and 2, 6, 12, 24, 48, 72 hours after CLP groups.

• 方法采用盲肠结扎穿孔术(CLP)复制脓毒症大鼠模型,144只大鼠随机分为正常对照组、假手术组及CLP术后2、6、12、24、48和72h组。