Methods Phosphorothioate oligodeoxynucleotide containing 2 CpG motifs was synthesized as the adjuvant of HBsAg.

• 方法以血源HBsAg为接种疫苗,人工合成含CpG基序的硫代磷酸寡脱氧核苷酸作为佐剂,以BALB/e小鼠作为实验动物进行免疫接种;