Methods MCC core pellets were produced by laboratory-scale centrifugal granulator.Yield (Y1) is the main response variable and the preparation conditions were optimized by central composite design.

• 方法 采用实验室规模的离心造粒机制备MCC空白母核，以产率（Y1）为主要评价指标，应用中心复合设计法优化制备工艺。