Methods At different time following thrombin was infused into ventricule, the permeability and the destroyed volume of blood brain barrier(BBB), water content and ion content were measured.

• 方法 在鼠脑室内注入凝血酶 ,于不同时间段测定丘脑组织的血脑屏障 (BBB)通透性、BBB破坏体积、水电解质含量 ,并以脑室内注入生理盐水和注入凝血酶后再注入水蛭素的动物为对照。