Methods A HPLC method was established for the determination of osthol in plasma after a single oral dose of 40mg/kg osthol in D-galacose and IBO induced aging rats model.

• 方法对D-半乳糖致亚急性衰老合并鹅膏蕈氨酸损毁Meynert核的AD大鼠模型,以40mg/kg的剂量灌胃蛇床子素,采用高效液相色谱法测定大鼠的蛇床子素血药浓度。