Methods 11 Patients with refractory partial onset seizures were chosen. Topriamate does were gradually increased to target doses (200 mg/day) and Primary AED or AEDS were maintained.

• 方法 选择难治性癫痫部分性发作 11例 ,保持原用AEDS不变 ,逐步递增托吡酯剂量 ,目标剂量 2 0 0mg/日。