Method:12cases of refractory and relapsed AML were treated with topotecan combined with chemotherapy,8 accepted 1 course,and the others accepted 2 courses.

• 方法:采用以拓扑替康为主的联合化疗方案治疗复发难治性急性髓系白血病12例,8例治疗1疗程,4例治疗2疗程。