Maternal teratogens that hae been reported in association with cleft lip and palate include alcohol, maternal phenylketonuria, hyperthermia, hydantoin, trimethadione, aminopterin, and methotrexate.

• 据报道与唇腭裂相关的母体的致畸因素有酒精、母体的苯丙酮尿症、高热、乙内酰脲、三甲双酮、氨喋呤、氨甲蝶呤等。