Materials and Methods: Uslng cyclic anhydride DTPA as a bifunctional chelat1ng a- gent, Gd3+ was attached to a monoclnal antihody (3D3).

• 材料与方法：用DTPA环二酸研与抗肺癌单抗3D3和Gd3~3+分别偶联，制备出Gd－DTPA－IgG：建立6只荷瘤裸鼠模型； 将Gd－DTPA－IgG按2mg单抗/只的剂量从尾静脉内注入；