Many researches show that Skp2 can interact with many cell cycle regulating factors including p27, and lead to their ubiquitination and degeneration.

• Skp2是F-box蛋白家族的一员。研究发现，Skp2可与包括p27在内的多种细胞周期调控因子相互作用，导致它们的泛素化降解。