METHODS:Morphine was subcutaneously injected into the rat with dose increasin g method to establish heroin dependence rat model. Rats of naloxone group receiv ed subcutaneously injection of 2 mg/kg of naloxone to excite abstinent symptoms.

• 方法:采用剂量递增法皮下注射吗啡建立大鼠吗啡依赖模型,然后对戒断组大鼠皮下注射2mg/kg的盐酸纳络酮激发戒断症状。