METHODS:Clodronate was synthesized by steps of condensation,chloration,pyrolysis and salifying from dibromomethane and triisopropyl phosphite.

• 方法：以二溴甲烷和亚膦酸三异丙酯为原料，经缩合、氯化、热裂解和成盐反应得到氯屈膦酸二钠。