METHODS The enteric coated omeprazole pellets were prepared with extrusion-spheronization and air-flow coating method and the formulation was optimized by orthogonal design.

• 方法采用挤出滚圆工艺及流化床包衣法制备了奥美拉唑肠溶微丸,并采用正交试验设计对处方进行了优化。