METHODS Strontium ranelate was synthesized from citric acid via decarboxylation,esterification,cyclization,alkylation,hydrolysis and salification.

• 方法以枸橼酸为起始原料,经过脱羧、酯化、环合、烷基化、水解成盐等多步反应生成终产物雷尼酸锶。